Antibody Mimetic Proteins™ 000
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Technology · Antibody Mimetic Proteins™

Disrupting antibodies

A synthetic protein that behaves like an antibody, small enough to cross the tissue it needs to treat. Delivered to the eye, the lung and the skin instead of the bloodstream.

Read the science
40×Smaller than a mAb
0Systemic exposure
Cell‑freeManufacturing route
Heat‑stableNo cold chain
FormatIgG monoclonal
Mass≈ 150 kDa
RouteIV infusion
Storage2–8 °C
01

The molecule isthe bottleneck

Conventional antibodies are large, complex molecules. That size is why they work in the bloodstream, and why they stall everywhere else.

  • SizeToo large to cross epithelial and mucosal tissue on their own.
  • StabilityFragile outside a narrow temperature and pH window.
  • CostLiving-cell expression keeps manufacturing expensive and slow.
02

Antibody MimeticProteins™

AMPs are engineered scaffolds that reproduce antibody-grade binding at roughly one fortieth of the size: small enough to move through tissue, rugged enough to survive the trip.

  • 40× smallerCrosses biological tissue rather than circulating past it.
  • Heat resistantHolds its fold under environmental conditions that denature a mAb.
  • Cell-freeSynthesised without living cells, collapsing cost and lead time.
03

Treat the tissue,not the patient

Because an AMP penetrates locally, it can be applied where the disease is. The dose stays in the tissue, so the systemic side-effect risk that shapes antibody therapy largely goes away.

  • EyesTopical delivery to the retina, the route diabetic retinopathy has never had.
  • LungsInhaled delivery straight to the mucosal surface.
  • SkinApplied on the tissue it is meant to act on.

Relative scale · schematic

1× smaller

A monoclonal antibody, drawn to scale.

IgG monoclonal · ≈150 kDa AMP

Tissue penetration

Small enoughto get through

An epithelial barrier is a filter. A 150 kDa antibody is turned away at the surface; an AMP is under the cut-off, so a drop, a spray or a cream becomes a viable route of administration.

APPLIED SURFACE TARGET TISSUE EPITHELIAL BARRIER

What changes

Four constraints,removed

01

It crosses tissue

Penetration, not circulation. An AMP is engineered under the size threshold that keeps antibodies out of the eye, the airway and the dermis.

02

It survives the shelf

Thermal stability replaces the 2–8 °C cold chain that governs how and where a monoclonal can be shipped and stored.

03

It is made without cells

Cell-free synthesis removes bioreactor capacity from the critical path, so a new binder is a manufacturing change rather than a programme.

04

It stays where it is put

Local administration keeps the dose in the target tissue, which takes systemic exposure, and the risk profile built on it, off the table.

The shift

From the infusionsuite to thebathroom shelf

Infusion centreA drop, a spray, a cream
Refrigerated logisticsAmbient shipping
Bioreactor campaignsCell-free synthesis
Systemic exposureLocal action only

Team · portraits to be photographed

The peoplebehind it

Four slots, shot on one consistent light setup against the brand navy, so the row reads as one piece rather than four different cameras.

Firstname Lastname
Co-founder & CEO
Firstname Lastname
Chief Scientific Officer
Firstname Lastname
Head of Protein Engineering
Firstname Lastname
Business Development

Next-generationantibody-liketherapeutics

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